Yeah, I had a major pruning session a few weeks back. Purely because there were a load of names in there I didn't even recognise, and others I couldn't recall ever having read, but whose stuff would inevitably clog my feed. Which sounds painful/distasteful/both.
But every time I try to continue the procedure, I get bored and give up.
I think I should probably have 200-300 meaningful followees, including publications. There are still plenty of one-off random clicks in my count of 400+.